解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科，口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学，全科和内科
医学，法律
医学，研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学，核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学，临床
abstract：:The in vitro and in vivo antimicrobial evaluation of the formulated ointment of alkaloidal extract of Enantia chlorantha Oliv. (Annonaceae) was the concern of this study. The alkaloidal fraction of the stem bark extract was formulated into simple ointment using British Pharmacopoeia formula for preparation of simple o...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:Keloids are characterized by overgrowth of connective tissue in the skin that arises as a consequence of abnormal wound healing. Normal wound healing is regulated by a complex set of interactions within a network of profibrotic and antifibrotic cytokines that regulate new extracellular matrix (ECM) synthesis and remod...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：:In normal and tumor cells, polyunsaturated fatty acids (PUFAs) act as intracellular second messengers, which play a role in signaling, proliferation and cell death. PUFAs have selective tumoricidal action and may alter sensitivity of tumor cells to cisplatin (CDDP), a commonly used anticancer agent. The aim of this st...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：:Diphenhydramine hydrochloride (DPH), a histamine H1-receptor antagonist, is widely used as antiallergic, antiemetic and antitussive drug found in many pharmaceutical preparations. In this study, a new reconstitutable syrup formulation of DPH was prepared because it is more stable in solid form than that in liquid form...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:This study was aimed at a biopharmaceutical evaluation of a new oral dosage form of tramadol hydrochloride (TH)--slow release tablets obtained by hot tableting of coated pellets, 100 mg (TP), compared to the conventional slow release tablets, Tramal Retard, 100 mg (TR). Both TP and TR formulations showed a similar rel...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:The cells continuously secrete a large number of different types of microvesicles including macro-and micro-molecules into the extracellular fluids. One of them are exosomes, which are nano-sized vesicles capable of transferring the DNAs, microRNAs, non-coding RNAs and lipids with or without direct cell to cell contac...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章,评审
doi：
更新日期：2014-07-01 00:00:00
abstract：:We verified the usefulness of "Rosen's postulate", i.e., the logarithm of reciprocal concentration of surfactant--log(1/cPi=20) by which the surface tension of a solution can be decreased by 20 mJ/m2 in relation to water (physiological value gamma25 = 48-52 mJ/m2) in the evaluation of the applicatory properties of cho...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：:Oxidative stress, increase of lipid peroxidation and resultant DNA damage are associated with pathophysiology of many human diseases such as acute and chronic CNS injuries and diseases, cancer, and also aging. This work was done to investigate whether water fraction from the hydroalcoholic extract of green leaf lettuc...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：:Signs and symptoms of secondary overactive bladder (OAB) are observed both in course of infravesical obstruction of urine outflow in patients with benign prostatic hyperplasia, and as a result of development of hemorrhagic cystitis (HC) following administration of cyclophosphamide (CP). Non-steroidal antiinflammatory ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：:Plant sources, chemical properties, bioactivities, as well as the synthesis of indigo dye and its derivatives, are reviewed in this paper. These compounds were chosen because of their significant benefits and scope of application as both coloring agents in the textile industry and as pharmacologically active natural p...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
abstract：:Abstract: The objective of this study was to fabricate topical formulations of diclofenac diethylamine (DD) using isopropyl myristate (IPM) and isopropyl palmitate (IPP) as permeation enhancers. Franz cell and bacterial cellulose were used as analytical instrument and diffusion membrane, respectively. Permeation enhan...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:Paracetamol/acetaminophen is one of the most popular and most commonly used analgesic and antipyretic drugs around the world, available without a prescription, both in mono- and multi-component preparations. It is the drug of choice in patients that cannot be treated with non-steroidal anti-inflammatory drugs (NSAID),...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章,评审
doi：
更新日期：2014-01-01 00:00:00
abstract：:The aim of this study was to determine the surface activity parameters of novel surface active compounds, products of catalytic oxyethylation of cholic acid, and their micellar adducts with selected lipophilic therapeutic agents (diclofenac, loratadine, naproxen and rutin). High solubility of lipophilic naproxen was o...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Two methods, spectrophotometric and chromatographic-densitometric ones, were developed for determination of losartan potassium, quinapril hydrochloride and hydrochlorothiazide in pharmaceutical preparations. Spectrophotometric method involved derivative spectrophotometry and zero order spectrophotometry. The measureme...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：:Solubilizing properties of aqueous solutions of a series of surface-active agents, products of oxyethylation of cholic acid, were examined in the present study. The content of oxyethylated segments determined by means of the 1H NMR method enabled the verification of the molecular mass of surfactants along with the cal...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：:In this paper, we describe our results of the synthesis and biological testing of analogues of the natural alkaloids olivacine and ellipticine. We have synthesized fourteen new 1-substituted pyrido[4,3-b]carbazole derivatives. All of them were tested in vitro for their anticancer activity on three human tumor cell lin...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：:A novel mutual prodrug (MA-P) consisting of mefenamic acid (MA) and paracetamol (P) has been synthesized as a gastrosparing NSAID, devoid of ulcerogenic side effects. The structure of synthesized drug was confirmed by elemental analysis, infrared spectroscopy, 1H NMR spectroscopy and mass spectrometry.The kinetics of ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：:The fullerene C60 has chemical properties which seem to predestinate it to be effective transporter of drugs in biological system. To prove this, the DFT/B3LYP (6-31G*) calculations were performed especially in order to determine the structures and energies of the inclusion complexes of C60 with small molecules. It wa...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：:Therapy of oral, esophageal and gastrointestinal candidiasis is still a common problem that can be solved by an administration of antimycotics. Major disadvantage of registered commercial antifungal medicinal products is their price, so the health care system and its payers may profit from extemporaneous compounding. ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：:Solid-phase extraction method followed by direct UV spectrophotometry at 264 nm was developed and applied for the selective ibuprofen determination in two-component formulation of ibuprofen and pseudoephedrine-HCl, combined powder which contains ibuprofen in the form of salt with L-arginine and 10% ibuprofen cream. Pr...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：:Methods for the modification of ganciclovir (GCV), acyclovir (ACV), cidofovir (CDV) and valganciclovir (VCDV) with boron cluster have been developed. Toxicity of the new derivatives was evaluated in adherent cells; no cytotoxicity was observed in five different cell lines up to 1000 microM with the exception of modifi...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：:In the search for novel biological agents, a series of new derivatives N-substituted 1,3-benzoxazol-2(3H)-one, 5-chloro-1,3-benzoxazol-2(3H)-one, 6-bromo-1,3-benzoxazol-2(3H)-one were prepared. All of the compounds were characterized by 1H NMR, 13C NMR and ESI MS spectra. Moreover, for compound 1 an Xray structure was...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:Convenient access to a large variety of OTC medicines presents patients with the opportunity for the self-treatment of many health problems. Yet this also brings on other health risks, especially to the elderly. A pointed lack of information about the safety of NSAIDs has been found among lay people, but no study in t...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:Chromatographic and densitometric method for determination of moxifloxacin in the presence of products of acidic hydrolysis was developed. The established method had suitable specificity, precision, good accuracy, and high sensitivity. In addition, stability of moxifloxacin in acidic solutions at temperature 90 degree...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Research data show that diuretics can have anticonvulsant properties. This study examined effects of ethacrynic acid, a loop diuretic, and hydrochlorothiazide, a thiazide-type diuretic, on the anticonvulsant activity of gabapentin, a newer antiepileptic drug, in the maximal electroshock seizure threshold test in mice....
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:In this study, a simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of nimesulide (NS), phenylephrine hydrochloride (PE), chlorpheniramine maleate (CPM) and caffeine anhydrous (CF) in pharmaceutical dosage forms. A reversed phase ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：:The aim of the present study was to investigate the effects of Withania somnifera (WS) on lipid peroxidation (LPO), activities of both non-enzymatic and enzymatic antioxidants and histopathological examination of pancreas in type 2 diabetic rats. Type 2 diabetes was induced by single intraperitoneal injection of STZ (...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：:Phytic acid (IP6) is an essential component of high fiber diet physiologically present in human large gut. It has been recognized to possess various significant health benefits effects including chemopreventive and have antineoplastic activity against various types of cancer. Moreover, its role in immune response thro...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：:In this paper, two simple, cost-effective and fast methods for quantification of methotrexate (MTX) in the macromolecular conjugates are presented. The method for analysis of total MTX in preparations was based on absorption spectrophotometry. Validation was performed by measuring absorbance at 372 nm of the sodium bi...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：:Aflatoxin belongs to the class of naturally occurring mycotoxins, food contaminants having potent carcinogenicity. We have evaluated the ameliorative role of black tea extract on aflatoxin-induced biochemical changes in the liver of albino male mice. Adult male mice were orally administered with 750 and 1500 pg of afl...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:The ethanolic extract of the root of Vitis vinifera (Vitaceae) was evaluated for hepatoprotective activity in rats with liver damage induced by carbon tetrachloride. The extract at an oral dose of 200 mg/kg exhibited a significant protective effect by lowering the serum levels of SGPT, SGOT, alkaline phosphatase and t...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:1H NMR and developed previously HPLC methods were applied to quantitative determination of norfloxacin in veterinary solution form for pigeon. Changes in concentration can lead to significant changes in the 1H chemical shifts of non-exchangeable aromatic protons as a result of extensive self-association phenomena. Thi...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:Mixed ligand complexes of dioxouranium(VI) of the type [UO2(Q)(L)-2H2O] have been synthesized using 8-hydroxyquinoline (HQ) as a primary ligand and N- and/or O- donor amino acids (HL) such as L-lysine, L-aspartic acid and L-cysteine as secondary ligands. The metal complexes have been characterized on the basis of elem...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:Pharmacophore mapping studies were undertaken for a series of molecules belonging to tetrasubstituted pyrazoles as canine COX-II inhibitors. A six point pharmacophore with 3 hydrogen bond acceptors (A), one hydrophobic group (H) and two aromatic rings (R) as pharmacophoric feature was developed. The pharmacophoric hyp...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:The pharmaceutical companies today are driven to create novel and more efficient tools to discover, develop, deliver and monitor the drugs. In this contest the development of rapid chromatographic method is crucial for the analytical laboratories. In precedent decade, substantial technological advances have been done ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章,评审
doi：
更新日期：2012-05-01 00:00:00
abstract：:Synergistic activity of Salvia officinalis and Cichorium intybus extracts and commonly used antibiotics, amoxicillin and chloramphenicol, were evaluated. Interactions between plant extracts and antibiotics were tested by checkerboard method and interpreted as FIC index. Staphylococcus aureus ATCC 25923, Escherichia co...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：:In this study the in vitro cytotoxic properties of ethanol extracts from the herbs, inflorescents and roots of selected Asteraceae species: Arctium lappa, Artemisia absinthium, Calendula officinalis, Centaurea cyanus, Tanacetum vulgare and Tragopogon pratensis on J-45.01 human acute T leukemia cell line was examined. ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：:Cross-sectional survey study was done, investigating whether information included in SmPC (changing often due to safety reasons) is actually used, properly used or not used at all by cardiologists, GP's (general practitioners), internists and internal diseases physicians. Conducting readability test of Patient Informa...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：:This study presents an application of the piecewise rational quadratic interpolant to the AUC calculation in the bioavailability study. The objective of this work is to find an area under the plasma concentration-time curve (AUC) for multiple doses of salbutamol sulfate sustained release tablets (Ventolin oral tablets...
journal_title：Acta poloniae pharmaceutica
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Ciprofloxacin is a chemotherapeutic agent mainly used in the treatment of the pulmonary and urinary tract infections but is also known for its anticancer properties. The aim of these study was to check the anticancer effect of ciprofloxacin on selected five cell lines. Human non-small cell lung cancer line A549, human...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
